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Dynamics of plasma hepatitis B virus levels after highly active antiretroviral therapy in patients with HIV infection.
- Source :
-
Journal of hepatology [J Hepatol] 2003 Dec; Vol. 39 (6), pp. 1028-35. - Publication Year :
- 2003
-
Abstract
- Background/aims: The optimal strategy to prescribe highly active antiretroviral therapy (HAART) in patients infected with both hepatitis B virus (HBV) and human immunodeficiency virus (HIV) remains unsettled. This study aimed to compare the HBV dynamics between HBeAg-positive and HBeAg-negative coinfected patients treated with lamivudine-containing HAART.<br />Methods: We retrospectively analyzed the serial changes of plasma HBV DNA levels in 24 HBsAg-positive HIV-infected patients who entered the HAART program. A polymerase chain reaction-based assay, capable of quantifying as few as 400 HBV copies/ml, was used. The median follow-up time was 18 months.<br />Results: HAART containing lamivudine 300 mg/day effectively suppressed plasma HBV-DNA to 10(-3)-10(-5)-fold of the baseline levels, but a multi-phasic decay of HBV DNA was observed. The later phases became flat, as a persistent residual HBV viremia, in eight of the studied 10 HBeAg-positive patients; in contrast, residual HBV viremia was not observed in the 10 HBeAg-negative patients studied (8/10 vs. 0/10, P=0.0007, Fisher's exact test). HAART without lamivudine did not suppress plasma HBV DNA levels in the remaining four patients.<br />Conclusions: HAART containing lamivudine 300 mg/day effectively suppress HBV replication in HBeAg-negative HIV/HBV-coinfected patients. Nevertheless, residual HBV replication persisted in most HBeAg-positive coinfected patients.
- Subjects :
- Adult
DNA, Viral blood
Female
HIV Infections complications
Hepatitis B e Antigens genetics
Hepatitis B virus genetics
Hepatitis B, Chronic complications
Humans
Male
Middle Aged
Polymerase Chain Reaction
Retrospective Studies
Anti-HIV Agents administration & dosage
Antiretroviral Therapy, Highly Active
HIV Infections drug therapy
Hepatitis B virus drug effects
Hepatitis B, Chronic drug therapy
Lamivudine administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0168-8278
- Volume :
- 39
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 14642622
- Full Text :
- https://doi.org/10.1016/s0168-8278(03)00416-1