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Increased macrophage inflammatory protein-1alpha and -1beta in BAL fluid of bronchiolitis obliterans organizing pneumonia.
- Source :
-
Respirology (Carlton, Vic.) [Respirology] 2003 Dec; Vol. 8 (4), pp. 461-6. - Publication Year :
- 2003
-
Abstract
- Objective: CC chemokines are mainly chemotactic for monocytes and lymphocytes. The aim of this study was to evaluate the involvement of the CC chemokines, macrophage inflammatory protein (MIP)-1alpha and MIP-1beta, in the pathogenesis of bronchiolitis obliterans organizing pneumonia (BOOP).<br />Methodology: The concentrations of MIP-1alpha and MIP-1beta in BAL fluid (BALF) obtained from patients with BOOP (n = 13) and control patients (CP, n= 18) were measured by enzyme-linked immunosorbent assay.<br />Results: MIP-1alpha in BALF was significantly higher in patients with BOOP (mean +/- SD; 123.8 +/- 98.0 pg/mL) than in CP (62.5 +/- 46.1 pg/mL). Significantly higher MIP-1beta was also detected in patients with BOOP (51.6 +/- 72.5 pg/mL) than in CP (6.4 +/- 3.7 pg/mL). The concentration of MIP-1alpha significantly correlated with the percentage of lymphocytes in BALF, and the concentration of MIP-1beta significantly correlated with the numbers of lymphocytes, neutrophils and eosinophils in BALF. Both MIP-1alpha and MIP-1beta in BALF were decreased after corticosteroid therapy and this was accompanied by decreased lymphocytes in BALF.<br />Conclusion: This study suggests that MIP-1alpha and MIP-1beta may play important roles in the recruitment of immuno-inflammatory cells into the lungs, and may contribute to the pathogenesis of BOOP.
- Subjects :
- Adrenal Cortex Hormones pharmacology
Adrenal Cortex Hormones therapeutic use
Adult
Aged
Bronchoalveolar Lavage Fluid cytology
Bronchoalveolar Lavage Fluid immunology
Case-Control Studies
Chemokine CCL3
Chemokine CCL4
Cryptogenic Organizing Pneumonia drug therapy
Female
Humans
Male
Middle Aged
Cryptogenic Organizing Pneumonia immunology
Macrophage Inflammatory Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1323-7799
- Volume :
- 8
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Respirology (Carlton, Vic.)
- Publication Type :
- Academic Journal
- Accession number :
- 14629649
- Full Text :
- https://doi.org/10.1046/j.1440-1843.2003.00496.x