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Kidney development conserved over species: essential roles of Sall1.

Authors :
Nishinakamura R
Source :
Seminars in cell & developmental biology [Semin Cell Dev Biol] 2003 Aug; Vol. 14 (4), pp. 241-7.
Publication Year :
2003

Abstract

The kidney develops in three stages: pronephros, mesonephros, and metanephros. Molecular mechanisms underlying these three steps are similar, and we can thus examine genetic cascades occurring during development. The induction system for pronephros in vitro has been established in Xenopus. Using this system, we isolated Sall1 that is essential for the initial step in metanephros formation. The potential mechanisms involved and future directions regarding kidney development are discussed.

Details

Language :
English
ISSN :
1084-9521
Volume :
14
Issue :
4
Database :
MEDLINE
Journal :
Seminars in cell & developmental biology
Publication Type :
Academic Journal
Accession number :
14627123
Full Text :
https://doi.org/10.1016/s1084-9521(03)00027-2