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Adult T-cell leukaemia/lymphoma-like human T-cell leukaemia virus-1 replication in infective dermatitis.
- Source :
-
British journal of haematology [Br J Haematol] 2003 Nov; Vol. 123 (3), pp. 406-12. - Publication Year :
- 2003
-
Abstract
- Adult T-cell leukaemia/lymphoma (ATLL) is a malignant T-cell proliferation that occurs in 3-5% of individuals infected with human T-cell leukaemia virus-1 (HTLV-1). HTLV-1 infection is also linked to the development of infective dermatitis (ID), an exudative dermatitis of children that has been proposed as a cofactor of ATLL. Here, HTLV-1 replication was investigated over time in a girl with ID and multiparasitic infestation including strongyloidiasis, a disease also known to predispose HTLV-1 carriers to ATLL. Quantitative polymerase chain reaction (PCR) revealed extremely high proviral loads. During the 2-year period of the present study, the proportion of circulating infected cells ranged between 12% and 36%. Quadruplicate linker-mediated PCR amplification of HTLV-1 flanking sequences identified a pattern of extensive and persistent oligoclonal expansion of infected lymphocytes. As viral loads, both the number and the degree of infected T-cell expansion were independent of treatment or clinical signs. However, the temporal fluctuation of proviral loads correlated significantly with the degree of infected T-cell expansion, but not with the overall number of detected clones. This pattern of HTLV-1 replication over time is very different from that observed in asymptomatic carriers and reminiscent of that observed in ATLL, a result consistent with the proposal of ID as an ATLL cofactor.
- Subjects :
- Antibodies, Viral blood
Antiviral Agents therapeutic use
Blotting, Western methods
Cell Division
Child
Clone Cells
Dermatitis parasitology
Female
Human T-lymphotropic virus 1 immunology
Humans
Lamivudine therapeutic use
Leukemia-Lymphoma, Adult T-Cell parasitology
Parasitic Diseases immunology
Parasitic Diseases virology
Polymerase Chain Reaction methods
Regression Analysis
Viral Load
Virus Replication
Dermatitis immunology
Dermatitis virology
Human T-lymphotropic virus 1 physiology
Leukemia-Lymphoma, Adult T-Cell immunology
T-Lymphocytes virology
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 123
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 14616998
- Full Text :
- https://doi.org/10.1046/j.1365-2141.2003.04565.x