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Antitumor effect of arsenic trioxide in murine xenograft model.
- Source :
-
Cancer science [Cancer Sci] 2003 Nov; Vol. 94 (11), pp. 1010-4. - Publication Year :
- 2003
-
Abstract
- Arsenic trioxide, As(2)O(3) (ATO), has been established to be an effective agent for treating acute promyelocytic leukemia, but its effect on solid tumors has not been fully explored. In the present study in a murine xenograft system, we found that ATO significantly inhibited tumor growth of the inoculated human hepatocellular carcinoma cell line HuH7 when administered either intravenously or intratumorally. Pathological examination revealed that ATO induced extensive cell death in the tumor. Some of the dead cells in intratumorally ATO-treated mice showed characteristic features of apoptosis, such as nuclear condensation and fragmentation, and were TUNEL-positive. The measurement of arsenic by using particle induced X-ray emission revealed that arsenic was accumulated more in the tumor than in brain, kidney or liver after the intravenous injection of ATO, which is consistent with the hemorrhagic cell death observed in ATO-treated tumor tissues. Thus, ATO appears to have potential for the treatment of solid tumors, as well as hematopoietic malignancies.
- Subjects :
- Animals
Apoptosis
Arsenic Trioxide
Brain drug effects
Brain metabolism
Carcinoma, Hepatocellular pathology
Humans
In Situ Nick-End Labeling
Injections, Intravenous
Kidney drug effects
Kidney metabolism
Liver drug effects
Liver metabolism
Liver Neoplasms pathology
Male
Mice
Mice, Inbred BALB C
Spectrometry, X-Ray Emission
Transplantation, Heterologous
Tumor Cells, Cultured transplantation
Antineoplastic Agents therapeutic use
Arsenicals therapeutic use
Carcinoma, Hepatocellular drug therapy
Liver Neoplasms drug therapy
Oxides therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1347-9032
- Volume :
- 94
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Cancer science
- Publication Type :
- Academic Journal
- Accession number :
- 14611680
- Full Text :
- https://doi.org/10.1111/j.1349-7006.2003.tb01393.x