Back to Search Start Over

Real-time observation of transient focal ischemia and hyperemia in cat brain.

Authors :
De Crespigny AJ
Wendland MF
Derugin N
Kozniewska E
Moseley ME
Source :
Magnetic resonance in medicine [Magn Reson Med] 1992 Oct; Vol. 27 (2), pp. 391-7.
Publication Year :
1992

Abstract

Gradient-recalled echo-planar (T2*-weighted) imaging was used to noninvasively monitor regional blood oxygenation state changes in real time during transient episodes of focal ischemia in cat brain. Varying ischemic intervals (12 s to 30 min) were caused by middle cerebral artery occlusion. A rapid signal drop was noted upon occlusion, due to deoxygenation of static blood in the ischemic tissues. Upon successful reperfusion, the signal intensity recovered immediately and increased above (overshot) the baseline level before slowly returning to normal. The "overshoot" response was strongly dependent on the duration of the ischemic interval and is thought to reflect reactive hyperemia.

Details

Language :
English
ISSN :
0740-3194
Volume :
27
Issue :
2
Database :
MEDLINE
Journal :
Magnetic resonance in medicine
Publication Type :
Academic Journal
Accession number :
1461120
Full Text :
https://doi.org/10.1002/mrm.1910270220