Back to Search
Start Over
Real-time observation of transient focal ischemia and hyperemia in cat brain.
- Source :
-
Magnetic resonance in medicine [Magn Reson Med] 1992 Oct; Vol. 27 (2), pp. 391-7. - Publication Year :
- 1992
-
Abstract
- Gradient-recalled echo-planar (T2*-weighted) imaging was used to noninvasively monitor regional blood oxygenation state changes in real time during transient episodes of focal ischemia in cat brain. Varying ischemic intervals (12 s to 30 min) were caused by middle cerebral artery occlusion. A rapid signal drop was noted upon occlusion, due to deoxygenation of static blood in the ischemic tissues. Upon successful reperfusion, the signal intensity recovered immediately and increased above (overshot) the baseline level before slowly returning to normal. The "overshoot" response was strongly dependent on the duration of the ischemic interval and is thought to reflect reactive hyperemia.
- Subjects :
- Animals
Brain metabolism
Brain pathology
Brain Diseases metabolism
Brain Diseases pathology
Cats
Cerebrovascular Circulation
Cerebrovascular Disorders
Hyperemia metabolism
Hyperemia pathology
Ischemic Attack, Transient metabolism
Ischemic Attack, Transient pathology
Reperfusion
Subtraction Technique
Brain Diseases blood
Echo-Planar Imaging methods
Hyperemia blood
Ischemic Attack, Transient blood
Oxygen blood
Oxygen Consumption
Subjects
Details
- Language :
- English
- ISSN :
- 0740-3194
- Volume :
- 27
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Magnetic resonance in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 1461120
- Full Text :
- https://doi.org/10.1002/mrm.1910270220