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Synthesis of benzylamides of dipeptides as potential inhibitors of plasmin.
- Source :
-
Die Pharmazie [Pharmazie] 2003 Oct; Vol. 58 (10), pp. 687-9. - Publication Year :
- 2003
-
Abstract
- Four benzylamides of dipeptides with the general formula: X-L-Lys-NH-CH2-C6H5, where X = L-or D-Leu and L-or D-Phe were prepared as potential inhibitors of plasmin. All of them influenced on the fibrynolytic activity of plasmin, but only D-Leu-L-Lys-NH-CH2-C6H5 inhibited the amidolytic activity of this enzyme. None of the tested compounds was an inhibitor of thrombin in an amidolytic test.
Details
- Language :
- English
- ISSN :
- 0031-7144
- Volume :
- 58
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Die Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 14609277