Back to Search
Start Over
Persistence with COX-2 inhibitors in managed care: an analysis of claims data.
- Source :
-
Managed care interface [Manag Care Interface] 2003 Oct; Vol. 16 (10), pp. 38-45. - Publication Year :
- 2003
-
Abstract
- Drug tolerability strongly influences patients' persistence with treatment. In this study, patterns of medication persistence with cyclooxygenase 2 (COX-2)-specific inhibitors and nonspecific nonsteroidal anti-inflammatory drugs (NSAIDs) were compared in a managed care setting. Pharmacy, enrollment, and medical claims data from 19 health plans were used to match subjects newly treated with celecoxib, rofecoxib, ibuprofen, naproxen, or diclofenac between July 1, 1999 and June 30, 2000. By using multiple regression analysis, users of COX-2-specific inhibitors were found to be 56.8% less likely to discontinue medication use and 60.3% less likely to switch treatment than were users of nonspecific NSAIDs (P < .001). Celecoxib users were 4.6% less likely to discontinue treatment than were rofecoxib users (P < .001). The greater persistence observed among users of COX-2 inhibitors might reflect improved treatment efficacy and patient satisfaction.
- Subjects :
- Anti-Inflammatory Agents, Non-Steroidal economics
Arthritis classification
Arthritis economics
Celecoxib
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors economics
Diclofenac therapeutic use
Female
Health Care Costs classification
Health Care Costs statistics & numerical data
Humans
Ibuprofen therapeutic use
Insurance Claim Review
Isoenzymes
Lactones therapeutic use
Male
Managed Care Programs organization & administration
Membrane Proteins
Middle Aged
Naproxen therapeutic use
Proportional Hazards Models
Prostaglandin-Endoperoxide Synthases
Pyrazoles
Regression Analysis
Sulfonamides therapeutic use
Sulfones
United States
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Arthritis drug therapy
Cyclooxygenase Inhibitors therapeutic use
Drug Utilization Review statistics & numerical data
Managed Care Programs economics
Patient Compliance statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1096-5645
- Volume :
- 16
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Managed care interface
- Publication Type :
- Academic Journal
- Accession number :
- 14606259