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Evaluation of a nisin-based germicidal formulation on teat skin of live cows.
- Source :
-
Journal of dairy science [J Dairy Sci] 1992 Nov; Vol. 75 (11), pp. 3185-90. - Publication Year :
- 1992
-
Abstract
- A purified preparation of the nontoxic antimicrobial peptide, nisin (AMBICIN N), was used in the formulation of a germicidal sanitizer suitable for use on cow teats. The germicidal activity of the formulation against mastitis pathogens was measured on teat skin of live cows. The nisin-based formulation gave a mean log reduction of 3.90 against Staphylococcus aureus and 4.22 log reduction against Escherichia coli after exposure for 1 min to the germicide. This activity was comparable with that exhibited by a 1% iodophor teat dip but was significantly greater than that exhibited by the .1 and .5% iodophors and by the .5% chlorhexidine digluconate teat dips. The nisin-based formulation showed little or no potential for skin irritation after multiple application to skin, but iodophor and chlorhexidine digluconate teat dips showed significant potential for skin irritation in comparable studies.
- Subjects :
- Animals
Anti-Infective Agents, Local toxicity
Chlorhexidine analogs & derivatives
Chlorhexidine pharmacology
Evaluation Studies as Topic
Female
Iodophors pharmacology
Irritants toxicity
Mammary Glands, Animal microbiology
Microbial Sensitivity Tests
Nisin toxicity
Skin microbiology
Anti-Infective Agents, Local pharmacology
Cattle microbiology
Mammary Glands, Animal drug effects
Nisin pharmacology
Skin drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0022-0302
- Volume :
- 75
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of dairy science
- Publication Type :
- Academic Journal
- Accession number :
- 1460143
- Full Text :
- https://doi.org/10.3168/jds.S0022-0302(92)78083-7