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[Structure and antiviral activity of adamantane-containing polymer preparation].
- Source :
-
Voprosy virusologii [Vopr Virusol] 2003 Sep-Oct; Vol. 48 (5), pp. 19-26. - Publication Year :
- 2003
-
Abstract
- New water-soluble antiviral chemical agents, containing 10 to 30% of adamantane derivatives (amino-, aminopropyl-adamantane-, aminomethyl- and rimantadine), which were conjugated with polycarboxylic matrixes of the divinyl ether and maleic anhydride copolymers (DIVEMA), were developed. The polymeric drugs exhibited a low cytotoxicity (4 to 10 times less than rimantadine) and a wide spectrum of antiviral activity against influenza viruses, including both the remantadine-resistant strains of A/PR/8/34 (H1N1) and the B/Saint-Petersburg strain/71/77 as well as against herpes viruses of type 1, parainfluenza viruses of types 1 and 3 and RS-virus. A reduction of the viral infection titer in their reproduction in sensitive cells' cultures was more than 2.0 Ig ID50. Complete inhibition of viral-specific syntheses, registered by immune-enzyme assay (IEA) and by hemagglutination test was observed at low infection doses ranging from 1 to 100 ID50. The efficiency of the antiviral effect depends on a drug's molecular weight and a structure of chemical bonds between the adamantane nucleus and the polymeric matrix.
- Subjects :
- Animals
Cell Line
Cytopathogenic Effect, Viral drug effects
Dogs
Dose-Response Relationship, Drug
Drug Resistance, Viral
Herpesviridae drug effects
Humans
Molecular Weight
Orthomyxoviridae drug effects
Orthomyxoviridae immunology
Polymers chemical synthesis
Pyran Copolymer chemical synthesis
Pyran Copolymer pharmacology
Respiratory Syncytial Viruses drug effects
Respirovirus drug effects
Respirovirus immunology
Rimantadine pharmacology
Structure-Activity Relationship
Virus Replication drug effects
Adamantane analogs & derivatives
Antiviral Agents pharmacology
Polymers pharmacology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0507-4088
- Volume :
- 48
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Voprosy virusologii
- Publication Type :
- Academic Journal
- Accession number :
- 14598476