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Iron lactate-induced osteomalacia in association with osteoblast dynamics.
- Source :
-
Toxicologic pathology [Toxicol Pathol] 2003 Nov-Dec; Vol. 31 (6), pp. 646-54. - Publication Year :
- 2003
-
Abstract
- Osteomalacia was induced in rats fed a diet containing 50,000 ppm (5%) iron lactate for 13 weeks. The histopathology and histomorphometrical dynamics of osteoblasts under this condition were examined. Bone histomorphometry of the proximal tibial metaphysis revealed that the osteoblast surface, osteoid volume, osteoid surface and labeled surface ratio, which are the parameters of bone formation had increased. The blood chemistry revealed the greatest elevation in the osteocalcin level; however, the parathyroid hormone (PTH) secretion and inorganic phosphorus level were very low. From the serum biochemical, histopathological and histomorphometrical findings, the bone lesion in iron lactate-overloaded rats was considered to be similar to low turnover osteomalacia showing decreased trabeculae in secondary spongiosa and increased lamellar osteoid. Furthermore, an iron-positive reaction was detected at the interface between osteoid and mineralized bone. In the bone lesions induced by chronic iron overload, osteoblast recruitment exceeded that of mineralization or, alternatively, the iron within osteoblasts along the trabecular bone suppressed the remodeling and led to an increase in osteoid thickness.
- Subjects :
- Administration, Oral
Animals
Diet
Disease Models, Animal
Iron Compounds administration & dosage
Iron Compounds analysis
Lactates administration & dosage
Male
Osteoblasts pathology
Osteocalcin blood
Osteomalacia blood
Osteomalacia pathology
Parathyroid Hormone blood
Phosphorus blood
Rats
Rats, Sprague-Dawley
Tibia drug effects
Tibia pathology
Iron Compounds toxicity
Lactates toxicity
Osteoblasts drug effects
Osteogenesis drug effects
Osteomalacia chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0192-6233
- Volume :
- 31
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Toxicologic pathology
- Publication Type :
- Academic Journal
- Accession number :
- 14585733
- Full Text :
- https://doi.org/10.1080/01926230390241990