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Synergistic interaction of T-786-->C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasm.
- Source :
-
Pharmacogenetics [Pharmacogenetics] 2003 Nov; Vol. 13 (11), pp. 683-8. - Publication Year :
- 2003
-
Abstract
- Objective: We previously reported that a T-786-->C polymorphism in the 5'-flanking region of the endothelial nitric oxide synthase gene and smoking were independently associated with coronary spasm; however, the interaction between this polymorphism and smoking remains to be elucidated.<br />Methods: We analyzed 209 men and 238 women who were admitted consecutively at our institution; all subjects received an intracoronary injection of acetylcholine (ACh) while undergoing coronary angiography for evaluation of chest pain: all subjects had no significant coronary stenosis. We divided these subjects into four groups: non-smokers with T/T genotype (Control Group A); non-smokers with C/T or C/C genotype (Group B); smokers with T/T genotype (Group C); and smokers with C/T or C/C genotype (Group D). We further examined quantitative coronary angiographies of the left anterior descending coronary artery in a subset of 54 consecutive men and 53 consecutive women.<br />Results: The frequencies of coronary spasm in Group B (male: 61%, female: 78%), Group C (62%, 59%) and Group D (91%, 92%) were significantly higher than in Group A (30%, 38%). In the males, ACh-induced vasoconstriction was greatest in Group D, and the change was weakest in Group A. In the females, ACh-induced vasoconstrictions were significantly greater in Groups B, C and D than in Group A. The T-786-->C polymorphism and smoking combine to increase the risk of coronary spasm.<br /> (Copyright 2003 Lippincott Williams & Wilkins)
- Subjects :
- Acetylcholine pharmacology
Aged
Asian People
Base Sequence genetics
Female
Humans
Isosorbide Dinitrate pharmacology
Logistic Models
Male
Middle Aged
Retrospective Studies
Risk Factors
Vasodilation drug effects
Vasodilator Agents pharmacology
Coronary Vasospasm genetics
Nitric Oxide Synthase genetics
Polymorphism, Single Nucleotide
Smoking adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0960-314X
- Volume :
- 13
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Pharmacogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 14583681
- Full Text :
- https://doi.org/10.1097/00008571-200311000-00004