[The antithromboxane activity of alpha- and omega-modified carbocyclic analogs of PGH1].

Authors :: Kuz'mitskiĭ BB
Bondar' NF
Malaeva LP
Source :: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1992 Jul-Aug; Vol. 55 (4), pp. 31-3.
Publication Year :: 1992
Abstract: In in vitro experiments on a model of arachidonate- and thrombin-induced platelet aggregation, analogues of PG endoperoxides displayed an antiaggregatory effect or stimulated spontaneous platelet aggregation in the whole blood of man and rabbits, but a slight antiaggregatory effect in the rabbit intact organism. The presence of the hydroxyl group instead of the routine alkyl omega-chain produced an antiaggregatory effect due to TxA2 receptor blockade.

Subjects :: Animals
Dose-Response Relationship, Drug
Drug Interactions
Female
Humans
In Vitro Techniques
Male
Mice
Platelet Aggregation drug effects
Platelet Aggregation Inhibitors pharmacology
Prostaglandins H pharmacology
Rabbits
Rats
Rats, Wistar
Receptors, Thromboxane antagonists & inhibitors
Structure-Activity Relationship
Prostaglandin Endoperoxides, Synthetic pharmacology
Thromboxane A2 antagonists & inhibitors

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