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Prophylaxis with meropenem of septic complications in acute pancreatitis: a randomized, controlled trial versus imipenem.
- Source :
-
Pancreas [Pancreas] 2003 Nov; Vol. 27 (4), pp. e79-83. - Publication Year :
- 2003
-
Abstract
- Objectives: Prophylactic antibiotics are helpful in decreasing the incidence of septic complications in acute pancreatitis. The aim of this study was to compare the efficacy of meropenem, a new carbapenem antibiotic, with that of imipenem, which is the standard prophylactic treatment in patients with severe acute pancreatitis.<br />Methods: One hundred seventy-six patients with necrotizing pancreatitis were prospectively randomized to prophylactic treatment with 0.5 g meropenem t.i.d. intravenously or 0.5 g imipenem q.i.d. intravenously. The occurrence of infection of pancreatic necrosis, rate of extrapancreatic infections, systemic and local complications, need for surgery, mortality rate, and length of hospitalization were recorded for each group. When a septic complication of pancreatic necrosis was suspected, fine needle aspiration with cultures of the sample was performed. Surgery was performed in cases of verified infected necrosis.<br />Conclusion: No difference was observed between patients treated with meropenem and those treated with imipenem in terms of incidence of pancreatic infection (11.4% versus 13.6%) and extrapancreatic infections (21.6% versus 23.9%) and clinical outcome. Meropenem is as effective as imipenem in preventing septic complications of patients with severe acute pancreatitis.
- Subjects :
- Adult
Aged
Aged, 80 and over
Bacteria drug effects
Bacteria isolation & purification
Female
Humans
Male
Meropenem
Middle Aged
Prospective Studies
Sepsis complications
Sepsis microbiology
Time Factors
Treatment Outcome
Anti-Bacterial Agents therapeutic use
Imipenem therapeutic use
Pancreatitis, Acute Necrotizing complications
Sepsis prevention & control
Thienamycins therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4828
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pancreas
- Publication Type :
- Academic Journal
- Accession number :
- 14576501
- Full Text :
- https://doi.org/10.1097/00006676-200311000-00018