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N-3 fatty acid-rich diet prevents early response of interleukin-6 elevation in trinitrobenzene sulfonic acid-induced enteritis.
- Source :
-
International journal of molecular medicine [Int J Mol Med] 2003 Nov; Vol. 12 (5), pp. 721-5. - Publication Year :
- 2003
-
Abstract
- Dietary fat is an important factor involved in the pathogenesis of inflammatory bowel disease (IBD). It remains unclear how n-3 and n-6 fatty acids modulate intestinal inflammation. In this study, we investigated the effects of n-3 and n-6 fatty acid-rich diets on trinitrobenzene sulfonic acid (TNBS)-induced enteritis. The rats were fed an n-3 or n-6 rich-diet for 12 days, and then starved for the following 2 days. An intraileal injection of TNBS was administered, and TNBS-enteritis subsequently developed. Macroscopic and histological examination was performed after 24 h. Serum cytokine levels were determined by ELISA. The n-6 fatty acid-rich diet markedly enhanced mucosal damage as compared to the n-3 fatty acid-rich diet. The damage score was significantly higher in the n-6 fatty acid-rich diet group (P<0.05). Histological changes in the mucosa were more severe in the n-6 fatty acid-rich diet group than in the n-3 fatty acid-rich group. Serum IL-6 levels were significantly higher in the n-6 fatty acid-rich diet group than in the n-3 fatty acid-rich group (P<0.05). On the other hand, there were no differences in serum TNF-alpha levels. The n-3 fatty acid-rich diet effectively reduced early mucosal inflammation in TNBS enteritis. The effects of the n-3 fatty acids were associated with blockage of mucosal IL-6 secretion. Our data suggest that n-3 fatty acid-rich diet may be applicable for enteral nutrition in the treatment of IBD patients.
- Subjects :
- Animal Feed
Animals
Diet
Disease Progression
Enteritis chemically induced
Enteritis pathology
Inflammatory Bowel Diseases blood
Inflammatory Bowel Diseases chemically induced
Inflammatory Bowel Diseases diet therapy
Inflammatory Bowel Diseases pathology
Male
Rats
Rats, Sprague-Dawley
Enteritis blood
Enteritis diet therapy
Interleukin-6 blood
Trinitrobenzenesulfonic Acid pharmacology
alpha-Linolenic Acid administration & dosage
alpha-Linolenic Acid therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1107-3756
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 14533000