Back to Search
Start Over
Positive T lymphocytotoxic cross-match in living donor liver transplantation.
- Source :
-
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society [Liver Transpl] 2003 Oct; Vol. 9 (10), pp. 1062-6. - Publication Year :
- 2003
-
Abstract
- The influence of lymphocytotoxic cross-match on survival or acute rejection in living donor liver transplantation (LDLT) has not been well examined. We analyzed 133 consecutive adult LDLT cases and assessed patient survival and acute rejection rates. Patients with a positive T lymphocytotoxic cross-match (n = 12) had a significantly higher chance of rejection within 6 weeks of LDLT (67% versus 28%, P <.001). All of the rejection episodes were successfully treated with bolus methylprednisolone therapy or anti-T cell monoclonal antibody. T lymphocytotoxic cross-match-positive grafts had no influence on patient survival (79% versus 90% at 3 years, P =.91). The results show that a positive cross-match graft should not be considered a contraindication for LDLT.
- Subjects :
- Acute Disease
Adult
Disease-Free Survival
Female
Graft Rejection immunology
Graft Rejection mortality
Graft Survival immunology
Humans
Incidence
Liver Transplantation mortality
Male
Middle Aged
Retrospective Studies
Survival Analysis
Cytotoxicity, Immunologic
Histocompatibility Testing
Liver Transplantation immunology
Living Donors
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1527-6465
- Volume :
- 9
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
- Publication Type :
- Academic Journal
- Accession number :
- 14526401
- Full Text :
- https://doi.org/10.1053/jlts.2003.50209