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Increased risk of cholestatic hepatitis C in recipients of grafts from living versus cadaveric liver donors.
- Source :
-
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society [Liver Transpl] 2003 Oct; Vol. 9 (10), pp. 1028-35. - Publication Year :
- 2003
-
Abstract
- Histologic injury caused by recurrent hepatitis C virus (HCV) has been reported in up to 90% of HCV-infected patients who undergo liver transplantation with a cadaveric graft. However, the natural history of HCV after living donor liver transplantation (LDLT) is not well described. We performed a retrospective analysis of 68 consecutive HCV-infected adult patients: 45 recipients of cadaveric grafts (CAD) were compared with 23 LDLT patients. Elevated serum transaminases, positive HCV RNA, and liver biopsy consistent with histologic evidence of HCV defined recurrence. When comparing CAD with LDLT, both the incidence of HCV recurrence and time to recurrence were not different. The overall incidence of severe sequelae of HCV recurrence, either cholestatic hepatitis, grade III-IV inflammation, and/or HCV-induced graft failure requiring retransplantation, was also not different when comparing CAD with LDLT. However, when comparing CAD versus LDLT, no CAD patient developed cholestatic hepatitis C, compared with 17% of LDLT who developed this complication (P =.001). Thus, in this patient population, the timing and incidence of HCV recurrence were not different when comparing CAD versus LDLT, but the incidence of cholestatic hepatitis was significantly greater in patients with HCV who underwent LDLT.
- Subjects :
- Adult
Cadaver
Female
Graft Rejection epidemiology
Hepatitis C, Chronic pathology
Humans
Incidence
Male
Middle Aged
Postoperative Complications mortality
Postoperative Complications pathology
Recurrence
Risk Factors
Survival Analysis
Cholestasis, Intrahepatic epidemiology
Hepatitis C, Chronic mortality
Hepatitis C, Chronic surgery
Liver Transplantation mortality
Living Donors statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1527-6465
- Volume :
- 9
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
- Publication Type :
- Academic Journal
- Accession number :
- 14526396
- Full Text :
- https://doi.org/10.1053/jlts.2003.50211