Back to Search
Start Over
Intracerebroventricular administration of ouabain as a model of mania in rats.
- Source :
-
Bipolar disorders [Bipolar Disord] 2003 Oct; Vol. 5 (5), pp. 362-5. - Publication Year :
- 2003
-
Abstract
- Background: Human bipolar illness is characterized by mood state- and diagnosis-associated abnormalities of cellular cation distribution and transport. These include reduced sodium pump activity and expression and increased intracellular sodium. If these alterations are related to the pathophysiology of the disease, rather than secondary or ancillary abnormalities, then one would expect that modeling of these changes in vivo would produce lithium-preventable behavioral abnormalities.<br />Methods: Ouabain, a potent inhibitor of the sodium pump, was administered intracerebroventricularly to male rats previously fed lithium-containing food or plain rat chow. Locomotion was then quantified in an open field.<br />Results: Ouabain increased locomotion 300% over baseline. Lithium pretreatment prevented the ouabain-induced hyperlocomotion response.<br />Conclusion: Inhibition of central nervous system sodium pump with ouabain produces a plausible animal model of mania. This model may be useful for preclinical screening of potential mood stabilizers.
- Subjects :
- Animals
Disease Models, Animal
Drug Administration Routes
Drug Interactions
Enzyme Inhibitors administration & dosage
Injections, Intraventricular
Lithium blood
Lithium therapeutic use
Locomotion drug effects
Male
Ouabain administration & dosage
Rats
Rats, Sprague-Dawley
Time Factors
Bipolar Disorder drug therapy
Enzyme Inhibitors therapeutic use
Ouabain therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1398-5647
- Volume :
- 5
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bipolar disorders
- Publication Type :
- Academic Journal
- Accession number :
- 14525557
- Full Text :
- https://doi.org/10.1034/j.1399-5618.2003.00053.x