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Reduction of brain dopamine concentration with dietary tyrosine plus phenylalanine depletion: an [11C]raclopride PET study.
- Source :
-
The American journal of psychiatry [Am J Psychiatry] 2003 Oct; Vol. 160 (10), pp. 1887-9. - Publication Year :
- 2003
-
Abstract
- Objective: Extracellular dopamine concentrations were estimated through measurement of [(11)C]raclopride binding with positron emission tomography after dietary manipulation of the dopamine precursors tyrosine and phenylalanine.<br />Method: Healthy male subjects were scanned on two occasions: once after receiving a balanced amino acid drink and once after receiving a drink mixture from which tyrosine and phenylalanine were omitted.<br />Results: Dietary tyrosine and phenylalanine depletion increased [(11)C]raclopride binding in the striatum by a mean of 6%. The change in [(11)C]raclopride binding correlated significantly with the fall in the ratio of tyrosine and phenylalanine to large neutral amino acids.<br />Conclusions: This is the first demonstration of an effect of a dietary manipulation on brain dopamine release in humans. This result provides support for the further investigation of the role of dietary manipulations in the treatment of neuropsychiatric disorders.
Details
- Language :
- English
- ISSN :
- 0002-953X
- Volume :
- 160
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The American journal of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 14514507
- Full Text :
- https://doi.org/10.1176/appi.ajp.160.10.1887