Back to Search
Start Over
Brain activation by disgust-inducing pictures in obsessive-compulsive disorder.
- Source :
-
Biological psychiatry [Biol Psychiatry] 2003 Oct 01; Vol. 54 (7), pp. 751-6. - Publication Year :
- 2003
-
Abstract
- Background: There is growing interest in the role of disgust in the pathogenesis of obsessive-compulsive disorder (OCD).<br />Methods: Eight OCD subjects with contamination preoccupations and eight gender- and age-matched healthy volunteers viewed pictures from the International Affective Picture System during functional magnetic resonance imaging scans.<br />Results: A different distribution of brain activations was found during disgust-inducing visual stimulation in several areas, most notably the insula, compared with neutral stimulation in both OCD subjects and healthy volunteers. Furthermore, whereas activation during the threat-inducing task in OCD subjects showed a pattern similar to that in healthy volunteers, the pattern of activation during the disgust-inducing task was significantly different, including greater increases in the right insula, parahippocampal region, and inferior frontal sites.<br />Conclusions: This pilot study supports the relevance of disgust in the neurocircuitry of OCD with contamination-preoccupation symptoms; future studies looking at non-OCD individuals with high disgust ratings, non-contamination-preoccupied OCD individuals, and individuals with other anxiety disorders are needed.
Details
- Language :
- English
- ISSN :
- 0006-3223
- Volume :
- 54
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 14512216
- Full Text :
- https://doi.org/10.1016/s0006-3223(03)00003-9