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Serum cystatin C reflects glomerular endotheliosis in normal, hypertensive and pre-eclamptic pregnancies.
- Source :
-
BJOG : an international journal of obstetrics and gynaecology [BJOG] 2003 Sep; Vol. 110 (9), pp. 825-30. - Publication Year :
- 2003
-
Abstract
- Objective: To study the correlation between serum cystatin C levels and renal structural changes in normal, hypertensive and pre-eclamptic pregnancy to evaluate it as a marker of the degree of renal involvement in pre-eclampsia.<br />Design: An observational prospective study.<br />Setting: University Hospital of Lund, Sweden.<br />Sample: Thirty-six women with hypertensive disease in pregnancy and 12 healthy pregnant women in the third trimester recruited from maternal health care centres in the catchment area of the hospital.<br />Methods: Renal biopsy samples were obtained from all participants and the degree of endotheliosis as well as the mean glomerular volume was evaluated by light microscopy in silver methenamin-stained sections. Serum cystatin C levels were measured and correlated to the structural changes.<br />Main Outcome Measures: Correlation among degree of glomerular endotheliosis, glomerular volume and serum cystatin C.<br />Results: Serum cystatin C levels differed between the different degrees of endotheliosis, showing a highly significant increasing linear trend. They also correlated significantly with glomerular volume (r = 0.60, P < 0.001). Mean serum urate and creatinine levels also increased with the degree of endotheliosis, but not above the reference interval for normal term pregnancy, even in pre-eclamptic women.<br />Conclusion: Serum cystatin C may be used as a marker, not only for impaired renal function, but also for the degree of glomerular endotheliosis and increase in glomerular volume in pregnancy. It may be of value in the monitoring of pregnancies complicated by pre-eclampsia.
- Subjects :
- Adult
Biomarkers blood
Cystatin C
Endothelium, Vascular
Female
Humans
Hypertension blood
Hypertension etiology
Hypertension pathology
Kidney Diseases blood
Kidney Diseases etiology
Kidney Glomerulus blood supply
Pre-Eclampsia blood
Pre-Eclampsia etiology
Pre-Eclampsia pathology
Pregnancy
Pregnancy Complications blood
Pregnancy Complications etiology
Pregnancy Complications, Cardiovascular blood
Pregnancy Complications, Cardiovascular etiology
Pregnancy Complications, Cardiovascular pathology
Prospective Studies
Cystatins blood
Kidney Diseases pathology
Kidney Glomerulus pathology
Pregnancy Complications pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1470-0328
- Volume :
- 110
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- BJOG : an international journal of obstetrics and gynaecology
- Publication Type :
- Academic Journal
- Accession number :
- 14511964