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Regulation of stanniocalcin 1 and 2 expression in the kidney by klotho gene.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2003 Oct 10; Vol. 310 (1), pp. 128-34. - Publication Year :
- 2003
-
Abstract
- The klotho gene product and stanniocalcin (STC) 1 and 2 are recently identified molecules implicated in calcium and phosphorus homeostasis. In the present study, we investigated the regulation of STC1 and STC2 gene expression in the kidney by klotho gene expression. Mice deficient in klotho expression (klotho mice) have hypercalcemia and hyperphosphatemia, and increased renal gene expression of STC1 and STC2 compared with wild-type mice. Administration of vitamin D or CaCl(2) to wild-type mice causes upregulation of STC1 but STC2 gene expression is not altered significantly. On the other hand, treatment of klotho mice with low phosphorus diet results in partial decrease in STC2 gene expression with normalization of hyperphosphatemia. These findings indicate that klotho gene expression plays a crucial role in the regulation of renal stanniocalcin gene expression in vivo, at least partly, through the control of circulating calcium and phosphate concentrations.
- Subjects :
- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase genetics
Animals
Calcium blood
Glucuronidase
Intercellular Signaling Peptides and Proteins
Intracellular Signaling Peptides and Proteins
Klotho Proteins
Mice
Phosphates blood
Gene Expression Regulation genetics
Glycoproteins genetics
Kidney metabolism
Membrane Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 310
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 14511659
- Full Text :
- https://doi.org/10.1016/j.bbrc.2003.08.131