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[Pathogenesis of Campylobacter fetus infection].
- Source :
-
Fukuoka igaku zasshi = Hukuoka acta medica [Fukuoka Igaku Zasshi] 2003 Jul; Vol. 94 (7), pp. 225-34. - Publication Year :
- 2003
-
Abstract
- Campylobacter fetus subsp. fetus is a zoonotic pathogen and cause opportunistic systemic infection in human who either are pregnant or have an underlying illness. Crystalline surface layer (S-layer), an external structure on the outer membrane is the prime virulence factor of this organism. S-layer is responsible for resistance to both leukocyte phagocytosis and the bactericidal effects of human serum. Antigenic variation of C. fetus surface antigen during infection also help the organism to escape from host immune-system and it is due to variation in the expression of the S-layer proteins (SLPs). C. fetus has multiple SLP-encoding genes and control the expression with inversion of a DNA segment containing the SLP promoter and/or homologous recombination.
- Subjects :
- Animals
Campylobacter fetus genetics
Gene Expression Regulation, Bacterial genetics
Gene Rearrangement
Humans
Promoter Regions, Genetic
Virulence genetics
Bacterial Proteins
Campylobacter Infections microbiology
Campylobacter fetus pathogenicity
Membrane Glycoproteins genetics
Membrane Glycoproteins immunology
Membrane Glycoproteins physiology
Virulence Factors
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0016-254X
- Volume :
- 94
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Fukuoka igaku zasshi = Hukuoka acta medica
- Publication Type :
- Academic Journal
- Accession number :
- 14509230