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Anxiolytic-like effects of preferential dopamine D3 receptor agonists in an animal model.
- Source :
-
Polish journal of pharmacology [Pol J Pharmacol] 2003 May-Jun; Vol. 55 (3), pp. 449-54. - Publication Year :
- 2003
-
Abstract
- The aim of the present study was to examine a potential anxiolytic-like action of (+)-7-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (7-OH-DPAT), a preferential dopamine D(3) receptor agonist, and (N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthylcarboxamide (BP 897), partial dopamine D(3) receptor agonist. Diazepam was used as a reference compound. The anxiolytic-like effect of those drugs was tested in the conflict drinking test (Vogel test) in male Wistar rats. The obtained results showed that 7-OH-DPAT and BP 897 (like diazepam) induced anxiolytic-like effects in the conflict drinking test. 7-OH-DPAT (0.05 and 0.1 mg/kg), BP 897 (0.5 mg/kg) and diazepam (5 and 10 mg/kg), tested at the effective doses in an animal model, did not affect motor coordination but produced significant reduction in exploratory activity in the open field test. These data suggest that preferential dopamine D(3) agonists may play a role in the therapy of anxiety, however, further studies are necessary to elucidate the mechanism of these actions.
- Subjects :
- Animals
Conflict, Psychological
Drinking Behavior drug effects
Electroshock
Injections, Intraperitoneal
Male
Models, Animal
Piperazines pharmacology
Rats
Rats, Wistar
Receptors, Dopamine D3
Tetrahydronaphthalenes pharmacology
Anti-Anxiety Agents pharmacology
Behavior, Animal drug effects
Dopamine Agonists pharmacology
Receptors, Dopamine D2 agonists
Subjects
Details
- Language :
- English
- ISSN :
- 1230-6002
- Volume :
- 55
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Polish journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 14506325