Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents.

Authors :: Jiang JB
Johnson MG
Defauw JM
Beine TM
Ballas LM
Janzen WP
Loomis CR
Seldin J
Cofield D
Adams L
Source :: Journal of medicinal chemistry [J Med Chem] 1992 Nov 13; Vol. 35 (23), pp. 4259-63.
Publication Year :: 1992
Abstract: A novel series of diaminoanthraquinones was discovered initially as protein kinase C inhibitors with IC50s in the 50-100 microM range. They exhibited potent tumor cell growth inhibitory activity in vitro without cross resistance to adriamycin. Further evaluation of two of the most active compounds NSC 639365 (3) and NSC 639366 (4) in human tumor cloning assay showed potent cytocidal activity. The results suggest therapeutical potentials against human tumors.

Subjects :: Anthraquinones chemistry
Anthraquinones therapeutic use
Cell Division drug effects
Humans
Protein Kinase C antagonists & inhibitors
Tumor Cells, Cultured drug effects
Tumor Stem Cell Assay
Anthraquinones chemical synthesis
Antineoplastic Agents chemical synthesis

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