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Neurologic and neuropsychological manifestations of human immunodeficiency virus infection in intravenous drug users without acquired immunodeficiency syndrome. Relationship to head injury.
- Source :
-
Archives of neurology [Arch Neurol] 1992 Nov; Vol. 49 (11), pp. 1169-75. - Publication Year :
- 1992
-
Abstract
- We examined 99 human immunodeficiency virus (HIV)-negative and 122 HIV-positive intravenous drug users (IVDUs) without acquired immunodeficiency syndrome (AIDS) to determine whether HIV-positive IVDUs had more neurologic and neuropsychological impairment than their HIV-negative counterparts. Controlling for age, education, drug use, history of head injury, and interactions between head injury and HIV status and drug use, HIV-positive subjects had more extrapyramidal signs and frontal release signs. These findings persisted when asymptomatic HIV-positive subjects without systemic signs of infection and HIV-negative subjects were compared. Neurologic findings were more severe in those with more systemic illness. Among those reporting a history of head injury with loss of consciousness, neuropsychological performance was significantly worse in the HIV-positive subjects, and this increased with severity of illness. This was not true in the group without head injury, suggesting an interaction between history of head injury and the seropositive state. No relationship was noted between head injury and either drug use or HIV state. Therefore, subtle neurologic and neuropsychological abnormalities may precede clinical evidence of AIDS in IVDUs and may be more evident in those with head injury.
- Subjects :
- Adult
Analysis of Variance
Craniocerebral Trauma complications
Craniocerebral Trauma physiopathology
Craniocerebral Trauma psychology
Female
HIV Infections etiology
HIV Infections physiopathology
HIV Infections psychology
Humans
Male
Nervous System Diseases physiopathology
Substance Abuse, Intravenous physiopathology
Substance Abuse, Intravenous psychology
HIV Infections complications
HIV Seropositivity
Nervous System Diseases etiology
Neuropsychological Tests
Substance Abuse, Intravenous complications
Subjects
Details
- Language :
- English
- ISSN :
- 0003-9942
- Volume :
- 49
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Archives of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 1444884
- Full Text :
- https://doi.org/10.1001/archneur.1992.00530350083023