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[Effects of benzyltetrahydropalmatine on rat portal vein and guinea pig myocardium].
- Source :
-
Zhongguo yao li xue bao = Acta pharmacologica Sinica [Zhongguo Yao Li Xue Bao] 1992 May; Vol. 13 (3), pp. 271-3. - Publication Year :
- 1992
-
Abstract
- In isolated rat portal vein, benzyltetrahydrophalmatine (BTHP) 0.3-100 mumol.L-1 dose-dependently increased the spontaneous mechanical activity. However, BTHP 300 mumol.L-1 showed an inhibitory effect on the spontaneous contraction. BTHP 200 mumol.L-1 reversed positive staircase phenomenon to negative ones in left atrium of guinea pig and inhibited the amplitude and Vmax and shortened the action potential duration (APD50) of the slow action potentials induced by high K+ (24 mmol.L-1) in guinea pig papillary muscles. BTHP reduced also the contractile force in papillary muscles of guinea pig. These results suggest that BTHP possesses calcium antagonistic effect in high concentration.
- Subjects :
- Action Potentials drug effects
Animals
Depression, Chemical
Female
Guinea Pigs
Heart Atria
In Vitro Techniques
Male
Papillary Muscles drug effects
Portal Vein drug effects
Rats
Alkaloids pharmacology
Berberine Alkaloids pharmacology
Calcium antagonists & inhibitors
Muscle Contraction drug effects
Muscle, Smooth, Vascular drug effects
Myocardial Contraction drug effects
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0253-9756
- Volume :
- 13
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhongguo yao li xue bao = Acta pharmacologica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 1442113