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[Modeling in biology. Structured analysis of intracellular calcium oscillations in electrically non-excitable cells].
- Source :
-
Die Naturwissenschaften [Naturwissenschaften] 1992 Jul; Vol. 79 (7), pp. 289-99. - Publication Year :
- 1992
-
Abstract
- In this paper a systematic approach to the mathematical modeling of intracellular Ca2+ oscillations is introduced. After a structured analysis a stochastic model of the system is derived which is numerically tractable by means of a stochastic simulation. A critical discussion of theoretical models for Ca2+ oscillations reveals that not all of the proposed mechanisms are consistent with experimental data. In addition, a model for oscillatory calcium waves is presented. Uncovering these mechanisms facilitates the design of anti-mitotic drugs interfering with Ca2+ metabolism.
Details
- Language :
- German
- ISSN :
- 0028-1042
- Volume :
- 79
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Die Naturwissenschaften
- Publication Type :
- Academic Journal
- Accession number :
- 1436114
- Full Text :
- https://doi.org/10.1007/BF01138706