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Mononuclear cell response in the liver of mice infected with hepatotoxigenic Campylobacter jejuni.
- Source :
-
Journal of medical microbiology [J Med Microbiol] 1992 Nov; Vol. 37 (5), pp. 326-31. - Publication Year :
- 1992
-
Abstract
- Intragastric inoculation with hepatotoxigenic strains of Campylobacter jejuni led to the death of mice during the late phase of infection. Histological study disclosed a massive infiltration of mononuclear cells in the liver, mimicking intrahepatic hypersensitivity. Neither enterotoxigenic nor enteroinvasive Escherichia coli induced such a lesion. However, the same histopathological change was induced by injecting the hepatotoxic factor of hepatotoxigenic C. jejuni intravenously on two occasions separated by 14 days. Neither a single injection of an increased dose of the hepatotoxic factor nor two injections, the second of which was heat-inactivated, induced this change. Pre-treatment with rabbit antibody to the hepatotoxic factor inhibited the development of the hepatic lesion. These results suggest that C. jejuni-induced hepatic lesions in mice may be caused, at least in part, by the active moiety of the hepatotoxic factor. The possible mechanisms by which the toxic factor induces hepatitis as a consequence of hypersensitivity are discussed in relation to Guillain-Barré syndrome and Reiter's syndrome associated with C. jejuni enteritis.
- Subjects :
- Animals
Bacterial Toxins toxicity
Female
Humans
Lethal Dose 50
Liver drug effects
Liver physiopathology
Liver Function Tests
Mice
Specific Pathogen-Free Organisms
Virulence
Bacterial Toxins biosynthesis
Campylobacter Infections pathology
Campylobacter jejuni pathogenicity
Leukocytes, Mononuclear pathology
Liver pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2615
- Volume :
- 37
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of medical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 1433254
- Full Text :
- https://doi.org/10.1099/00222615-37-5-326