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Acute tryptophan depletion: a method of studying antidepressant action.
- Source :
-
The Journal of clinical psychiatry [J Clin Psychiatry] 1992 Oct; Vol. 53 Suppl, pp. 28-35. - Publication Year :
- 1992
-
Abstract
- Serotonin (5-HT) has been implicated in the pathophysiology of depressive syndromes and in the mechanism of antidepressant drug action. Rapid dietary depletion of tryptophan (TRP) provides a paradigm for studying the role of 5-HT in depressed patients. Drug-free depressed patients do not show mood changes during TRP depletion but about one third have a clinically apparent, transient improvement in mood on return to normal TRP intake. Depressed patients in clinical remission after 6 to 8 weeks of antidepressant therapy experience a transient depressive relapse during acute TRP depletion. The significance of these findings will be discussed. Tryptophan depletion in other psychiatric syndromes will also be reviewed.
- Subjects :
- Antidepressive Agents pharmacology
Brain metabolism
Brain Chemistry drug effects
Depressive Disorder physiopathology
Diet
Humans
Mental Disorders metabolism
Mental Disorders physiopathology
Receptors, Serotonin drug effects
Receptors, Serotonin physiology
Research Design
Serotonin metabolism
Tryptophan administration & dosage
Tryptophan metabolism
Antidepressive Agents therapeutic use
Depressive Disorder drug therapy
Serotonin physiology
Tryptophan deficiency
Subjects
Details
- Language :
- English
- ISSN :
- 0160-6689
- Volume :
- 53 Suppl
- Database :
- MEDLINE
- Journal :
- The Journal of clinical psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 1429482