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Effects of cefaclor, cefetamet and Ro 40-6890 on inflammatory responses of human granulocytes.
- Source :
-
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 1992 Jul; Vol. 30 (1), pp. 57-66. - Publication Year :
- 1992
-
Abstract
- The effect of three cephalosporins (cefetamet, cefaclor and Ro 40-6890) upon human granulocytes and their ability to modulate the chemiluminescence response, phagocytose, kill bacteria and generate leukotrienes was studied. In the presence of the cephalosporins there was a significant increase in phagocytosis of Escherichia coli. The bactericidal activity of human granulocytes for several other bacteria was also enhanced. Cefetamet and cefaclor increased the chemiluminescence response of human neutrophils to Pseudomonas aeruginosa and Proteus mirabilis in contrast to Ro 40-68790, which decreased the chemiluminescence response. The cephalosporins decreased the synthesis of leukotrienes from human neutrophils after stimulation with Escherichia coli and Staphylococcus aureus. These data emphasize the immunomodulatory functions of various cephalosporins on cells involved in host defence.
- Subjects :
- Ceftizoxime pharmacology
Cell Adhesion drug effects
Chemotaxis, Leukocyte drug effects
Humans
In Vitro Techniques
Leukotrienes biosynthesis
Luminescent Measurements
Neutrophils drug effects
Phagocytosis drug effects
Cefaclor pharmacology
Ceftizoxime analogs & derivatives
Cephalosporins pharmacology
Granulocytes drug effects
Inflammation physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0305-7453
- Volume :
- 30
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of antimicrobial chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 1429337
- Full Text :
- https://doi.org/10.1093/jac/30.1.57