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Expression of the bcl-2 oncogene product and chromosomal translocation t(14;18) in Hodgkin's disease.
- Source :
-
Human pathology [Hum Pathol] 1992 Nov; Vol. 23 (11), pp. 1205-9. - Publication Year :
- 1992
-
Abstract
- The B-cell lymphoma/leukemia oncogene bcl-2 takes part in crucial regulatory events in B-cell maturation and differentiation. The reciprocal chromosomal translocation t(14;18), leading to overexpression of this oncogene, can be found in the majority of follicular lymphomas and much less frequently in B-cell leukemias and diffuse lymphomas. We have studied the expression of this protein in different subtypes of Hodgkin's disease using monoclonal antibodies directed against a formalin-resistant epitope of the bcl-2 protein and also have investigated these cases by polymerase chain reaction for evidence of the t(14;18) translocation. We were particularly interested to determine whether nodular paragranuloma (lymphocyte-predominant, nodular), which differs from other subtypes of Hodgkin's disease by virtue of the B-cell nature of its malignant cell population, is characterized by expression of the bcl-2 protein. Our data indicate that only a small number of nodular paragranulomas express the bcl-2 protein and that the expression is not specific for this type of Hodgkin's disease. In a smaller number of cases this expression of bcl-2 could be explained by the presence of the translocation t(14;18).
- Subjects :
- Antibodies, Monoclonal
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Humans
Immunoenzyme Techniques
Polymerase Chain Reaction
Proto-Oncogene Proteins c-bcl-2
Reed-Sternberg Cells pathology
Gene Expression
Hodgkin Disease genetics
Hodgkin Disease pathology
Proto-Oncogene Proteins analysis
Translocation, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0046-8177
- Volume :
- 23
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Human pathology
- Publication Type :
- Academic Journal
- Accession number :
- 1427749
- Full Text :
- https://doi.org/10.1016/0046-8177(92)90286-c