Back to Search
Start Over
Neurotoxic effect of prenatal exposure to MPTP on the dopaminergic systems of the marmoset brain.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1992 Jul 07; Vol. 217 (2-3), pp. 211-3. - Publication Year :
- 1992
-
Abstract
- MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was incidentally administered to pregnant marmosets during the whole gestational period, except for the last 15 days before term. The infant monkeys were killed 5 months after birth, and dopamine and its metabolites were measured in the striatum and the nucleus accumbens. Prenatal exposure to MPTP produced a marked dopamine depletion in these brain regions of the offspring, showing that MPTP is able to cross the placental barrier in primates.
- Subjects :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration & dosage
3,4-Dihydroxyphenylacetic Acid metabolism
Adolescent
Animals
Callithrix
Female
Homovanillic Acid metabolism
Humans
Pregnancy
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine pharmacology
Corpus Striatum metabolism
Dopamine metabolism
Nucleus Accumbens metabolism
Prenatal Exposure Delayed Effects
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 217
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1425940
- Full Text :
- https://doi.org/10.1016/0014-2999(92)90873-3