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Is small bowel bacterial overgrowth of pathogenic significance in persistent diarrhea?
- Source :
-
Acta paediatrica (Oslo, Norway : 1992). Supplement [Acta Paediatr Suppl] 1992 Sep; Vol. 381, pp. 108-13. - Publication Year :
- 1992
-
Abstract
- Bacterial overgrowth in the upper small intestine is postulated to cause persistent diarrhea. We compared the fecal and upper intestinal flora in 82 patients with persistent diarrhea aged < or = 36 months and weight-for-length < or = 90% of National Center for Health Statistics standards (NCHS) and 39 non-diarrheal children with age < or = 36 months, nutritionally matched with the patients and residing in the same environment. In the age groups < or = 12 months and > 12 months the duodenal fluid bacterial counts > or = 10(5)/ml were found with similar frequency in patients and controls for aerobic (p = 0.33; p = 0.1) and anaerobic (p = 1.0; p = 1.0) bacteria. However, the duodenal isolation rates of any aerobic bacteria (p < 0.05) without regard to counts and Enterobacteriaceae (p = 0.06) were higher in patients than in controls. Colonization with Enterobacteriaceae was directly correlated with increased stool weight over a 7-day observation period (p < 0.05; p < 0.01). One or more pathogens were isolated in the feces of 58% of the patients and 43.8% of the controls. Enteroadherent E. coli of the localized [EAEC-L] (p < 0.01) and aggregative [EAggEC] (p = 0.22) phenotypes were isolated more commonly from the feces of patients. The duodenal fluid detection rates for Klebsiella were significantly greater (p < 0.01) in patients, while Giardia lamblia was detected more commonly in the duodenal fluid of controls (p < 0.01). The presence of specific pathogens in the feces did not seem to be related to the extent of small bowel colonization.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Animals
Anti-Bacterial Agents therapeutic use
Bacterial Adhesion
Case-Control Studies
Child Nutrition Disorders complications
Child Nutrition Disorders microbiology
Child Nutrition Disorders parasitology
Child, Preschool
Chronic Disease
Colony Count, Microbial
Diarrhea complications
Diarrhea drug therapy
Diarrhea, Infantile complications
Diarrhea, Infantile drug therapy
Diarrhea, Infantile microbiology
Duodenum parasitology
Escherichia coli growth & development
Escherichia coli physiology
Feces parasitology
Giardia isolation & purification
Humans
Infant
Bacteria, Aerobic growth & development
Bacteria, Anaerobic growth & development
Diarrhea microbiology
Duodenum microbiology
Feces microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 0803-5326
- Volume :
- 381
- Database :
- MEDLINE
- Journal :
- Acta paediatrica (Oslo, Norway : 1992). Supplement
- Publication Type :
- Academic Journal
- Accession number :
- 1421924
- Full Text :
- https://doi.org/10.1111/j.1651-2227.1992.tb12382.x