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Growth hormone treatment in Turner syndrome accelerates growth and skeletal maturation. Dutch Growth Hormone Working Group.
- Source :
-
European journal of pediatrics [Eur J Pediatr] 1992 Jul; Vol. 151 (7), pp. 477-81. - Publication Year :
- 1992
-
Abstract
- Sixteen girls with Turner syndrome (TS) were treated for 4 years with biosynthetic growth hormone (GH). The dosage was 4 IU/m2 body surface s.c. per day over the first 3 years. In the 4th year the dosage was increased to 6 IU/m2 per day in the 6 girls with a poor height increment and in 1 girl oxandrolone was added. Ethinyl oestradiol was added after the age of 13. Mean (SD) growth velocities were 3.4 (0.9), 7.2 (1.7), 5.3 (1.3), 4.3 (2.0) and 3.6 (1.5) cm/year before and in the 1st, 2nd, 3rd and 4th year of treatment. Skeletal maturation advanced faster than usual in Turner patients especially in the younger children. Although the mean height prediction increased by 5.6 cm and 11 of the 16 girls have now exceeded their predicted height, the height of the 4 girls who stopped GH treatment exceeded the predicted adult height by only 0 to 3.4 cm.
- Subjects :
- Adolescent
Age Determination by Skeleton
Child
Female
Growth Hormone therapeutic use
Hormones therapeutic use
Human Growth Hormone
Humans
Recombinant Proteins
Turner Syndrome physiopathology
Bone Development drug effects
Growth drug effects
Growth Hormone analogs & derivatives
Turner Syndrome drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0340-6199
- Volume :
- 151
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 1396905
- Full Text :
- https://doi.org/10.1007/BF01957747