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The influence of vancomycin concentration and the pH of plasma on vancomycin protein binding.
- Source :
-
Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 1992 Aug; Vol. 28 (1), pp. 57-60. - Publication Year :
- 1992
-
Abstract
- A review of numerous studies of the protein binding of vancomycin suggests major discrepancies among their results. The reported percent protein binding of vancomycin varies from 0% to 98%. The influence of pH and concentration on the protein binding of vancomycin was investigated in this study. There was a significant difference (p < 0.001) in percent protein binding in vancomycin-spiked plasma samples across the pH range of 7.0-8.0. There was no significant difference (p > 0.05) in percent protein binding in vancomycin-spiked plasma samples across the concentration range of 2-80 mg/L. It is likely that some of the variation reported to date may be due to a lack of control of pH during the measurement of protein binding of vancomycin.
Details
- Language :
- English
- ISSN :
- 1056-8719
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of pharmacological and toxicological methods
- Publication Type :
- Academic Journal
- Accession number :
- 1392060
- Full Text :
- https://doi.org/10.1016/1056-8719(92)90066-a