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Quantifying anti-inflammatory agents' potency by measurement of response to dinitrochlorobenzene challenge.
- Source :
-
Journal of dermatological science [J Dermatol Sci] 1992 Jul; Vol. 4 (1), pp. 1-5. - Publication Year :
- 1992
-
Abstract
- Classical assays of topical corticosteroid potency based on the induction of vasoconstriction are unsatisfactory for a number of reasons. These include the doubtful relevance of vasoconstriction to immune inflammation, and more importantly, the inability to compare non-steroidal agents with corticosteroids. Here we describe a simple assay in which the inhibitory effect of agents upon delayed type hypersensitivity response to dinitrochlorobenzene can be quantified by measurements of reaction as skinfold thickness with Harpenden callipers. Using this system we have confirmed the greater potency of clobetasol propionate (Dermovate) compared with betamethasone valerate (Betnovate), but the evidence for an inhibitory effect of topical cyclosporin (10% cream) compared with base on this response is less convincing.
- Subjects :
- Administration, Topical
Adult
Betamethasone Valerate administration & dosage
Clobetasol administration & dosage
Clobetasol analogs & derivatives
Cyclosporine administration & dosage
Dose-Response Relationship, Drug
Female
Humans
Hypersensitivity, Delayed drug therapy
Hypersensitivity, Delayed pathology
Male
Middle Aged
Skin immunology
Skin pathology
Skinfold Thickness
Anti-Inflammatory Agents administration & dosage
Dinitrochlorobenzene immunology
Skin drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0923-1811
- Volume :
- 4
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of dermatological science
- Publication Type :
- Academic Journal
- Accession number :
- 1390452
- Full Text :
- https://doi.org/10.1016/0923-1811(92)90048-g