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Evaluation of intraventricular teicoplanin for the treatment of neurosurgical shunt infections.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 1992 Aug; Vol. 15 (2), pp. 285-9. - Publication Year :
- 1992
-
Abstract
- Seven patients with staphylococcal neurosurgical shunt infections were treated with intraventricular teicoplanin. Two infants received 5 mg/d, three patients received 20 mg/d, and two patients received 20 mg every other day. Six of these patients also received intravenous antibiotics. Three patients had infections caused by methicillin-susceptible Staphylococcus epidermidis, and one patient had an infection caused by methicillin-resistant S. epidermidis. Three patients were infected with Staphylococcus aureus (one with a methicillin-resistant strain and two with methicillin-susceptible strains). The mean duration of intraventricular therapy was 16 days. Sterilization of cerebrospinal fluid (CSF) was obtained after an average of 4.4 days. All patients were cured both clinically and microbiologically. No significant adverse effects were observed in any patients. Penetration of teicoplanin into the CSF after intravenous administration was poor. However, after intraventricular administration, high and prolonged peak and trough levels of teicoplanin were detected in the CSF. Bactericidal activity of the CSF was remarkable, exceeding the 1:8 dilution in the majority of the cases. The alternate-day schedule of intraventricular administration of teicoplanin was as effective as the once-daily regimen.
- Subjects :
- Adolescent
Adult
Anti-Bacterial Agents adverse effects
Anti-Bacterial Agents cerebrospinal fluid
Bacterial Infections cerebrospinal fluid
Cerebrospinal Fluid microbiology
Female
Follow-Up Studies
Glycopeptides adverse effects
Glycopeptides cerebrospinal fluid
Glycopeptides therapeutic use
Humans
Infant
Injections, Intraventricular
Male
Middle Aged
Teicoplanin
Anti-Bacterial Agents therapeutic use
Bacterial Infections drug therapy
Cerebrospinal Fluid Shunts adverse effects
Gram-Positive Bacteria drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1058-4838
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 1387805
- Full Text :
- https://doi.org/10.1093/clinids/15.2.285