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Evidence for a viral superantigen in humans.
- Source :
-
Nature [Nature] 1992 Aug 06; Vol. 358 (6386), pp. 507-10. - Publication Year :
- 1992
-
Abstract
- Superantigens bind class II major histocompatibility proteins and stimulate powerful proliferative responses of T lymphocytes bearing particular V beta sequences as part of their alpha beta antigen receptor. Exogenous bacterial superantigens are responsible for food poisoning and toxic shock syndrome. Murine virus-encoded self-superantigens induce clonal deletion of T lymphocytes. Although superantigen-like properties have been suggested for human immunodeficiency virus-1, no viral superantigen has been identified in humans. Here we report that the nucleocapsid of the rabies virus is an exogenous superantigen specific for V beta 8 human T lymphocytes which binds to HLA class II alpha-chains.
- Subjects :
- Antigen-Presenting Cells physiology
Antigens, Viral metabolism
B-Lymphocytes physiology
Capsid immunology
Enterotoxins immunology
HLA-D Antigens immunology
Humans
Receptors, Antigen, T-Cell, alpha-beta immunology
Viral Core Proteins immunology
Antigens, Viral immunology
Bacterial Toxins
Rabies virus immunology
Superantigens
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0028-0836
- Volume :
- 358
- Issue :
- 6386
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 1386410
- Full Text :
- https://doi.org/10.1038/358507a0