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Lymphoepitheliomalike carcinoma of the skin. A case report with immunophenotypic analysis and in situ hybridization for Epstein-Barr viral genome.
- Source :
-
The American journal of surgical pathology [Am J Surg Pathol] 1992 Sep; Vol. 16 (9), pp. 909-13. - Publication Year :
- 1992
-
Abstract
- Lymphoepithelioma is a malignant epithelial neoplasm of the nasopharynx. Similar malignancies--lymphoepitheliomalike carcinomas--of salivary glands, thymus, larynx, lung, stomach, and uterus have been described. We present here a case of lymphoepitheliomalike carcinoma of the skin in an 84-year-old woman. Histologically this neoplasm presented as a fairly discrete dermal aggregate of syncytial nests of epithelioid-appearing cells that displayed no squamous or glandular differentiation, surrounded by a dense lymphocytic infiltrate. Results of immunophenotypic studies showed expression of high molecular weight cytokeratins and increased density of dermal dendrocytes within and adjacent to the tumor. No Epstein-Barr viral genomic sequences were detected by in situ hybridization, which suggests that cutaneous neoplasms may have different etiologic agents compared with similar tumors, found to be associated with this DNA-containing virus, arising in extracutaneous sites. The combined light microscopic and immunohistochemical assessment of this rate cutaneous neoplasm permits distinction of lymphoepitheliomalike carcinoma from benign/malignant lymphoproliferative disorders or neuroendocrine carcinomas.
- Subjects :
- Aged
Aged, 80 and over
Carcinoma, Squamous Cell chemistry
Carcinoma, Squamous Cell pathology
DNA, Viral genetics
Female
Herpesvirus 4, Human genetics
Humans
Immunohistochemistry
Immunophenotyping
Keratins analysis
Nucleic Acid Hybridization
Skin Neoplasms chemistry
Skin Neoplasms pathology
Carcinoma, Squamous Cell genetics
Skin Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0147-5185
- Volume :
- 16
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The American journal of surgical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 1384378