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Proto-oncogene c-jun and c-fos messenger RNAs increase in the liver of carnitine-deficient juvenile visceral steatosis (jvs) mice.
- Source :
-
FEBS letters [FEBS Lett] 1992 Oct 12; Vol. 311 (1), pp. 63-6. - Publication Year :
- 1992
-
Abstract
- We determined the mRNA levels of c-jun and c-fos in the liver of C3H-H-2 degrees jvs mice. Both were higher in jvs mice than in normal mice. The level of c-jun mRNA increased gradually after birth, but in the control mice there was almost no change. In addition, alpha-fetoprotein and aldolase A mRNA levels were also higher than in normal littermates. These results suggest that the pattern of the gene expression in jvs mice partly resembles the one that occurs in undifferentiated hepatocytes and/or hepatocellular carcinoma.
- Subjects :
- Aging
Animals
Animals, Newborn metabolism
Fructose-Bisphosphate Aldolase genetics
Genes, fos
Genes, jun
Homozygote
Mice
Mice, Mutant Strains metabolism
Transcription, Genetic
alpha-Fetoproteins genetics
Carnitine deficiency
Lipid Metabolism, Inborn Errors genetics
Liver metabolism
Proto-Oncogenes
RNA, Messenger biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 311
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 1383034
- Full Text :
- https://doi.org/10.1016/0014-5793(92)81368-v