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Soluble glycoprotein D blocks herpes simplex virus type 1 infection of rat eyes.
- Source :
-
Journal of virology [J Virol] 1992 Sep; Vol. 66 (9), pp. 5183-9. - Publication Year :
- 1992
-
Abstract
- Herpes simplex virus type 1 (HSV-1) ocular infection in rats was blocked by treating the eyes with UV-inactivated virions containing glycoprotein D (gD) prior to ocular challenge. In contrast, rats treated with UV-inactivated virions lacking gD were not protected. A soluble, truncated form of HSV-2 gD (gD-2t) also protected against ocular infection. Treatment with gD-2t not only reduced mortality but also restricted progression of pathology and reduced the amount of viral antigen in the cornea. Host antibody or alpha/beta interferon responses to the gD-2t treatment were not detected. These results are similar to those observed in cell culture (D. C. Johnson, R. L. Burke, and T. Gregory, J. Virol. 64:2569-2576, 1990). The in vivo effect of exogenous gD is consistent with blocking of a cell surface gD receptor or with an inhibitory interaction of gD with virions.
- Subjects :
- Animals
Antibodies, Viral biosynthesis
Female
Immunohistochemistry
Interferons biosynthesis
Keratitis, Herpetic immunology
Keratitis, Herpetic microbiology
Rats
Rats, Inbred F344
Receptors, Virus physiology
Simplexvirus immunology
Simplexvirus radiation effects
Solubility
Survival Analysis
Ultraviolet Rays
Virulence
Keratitis, Herpetic prevention & control
Simplexvirus pathogenicity
Viral Envelope Proteins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-538X
- Volume :
- 66
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 1380093
- Full Text :
- https://doi.org/10.1128/JVI.66.9.5183-5189.1992