Back to Search
Start Over
Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies.
- Source :
-
Acta neurologica Scandinavica [Acta Neurol Scand] 1992 Jun; Vol. 85 (6), pp. 383-90. - Publication Year :
- 1992
-
Abstract
- In an unselected series of patients with monoclonal gammopathy of undetermined significance (MGUS) we found neuropathy in 2 of 34 patients with IgG (6%), 2 of 14 with IgA (14%), and 8 of 26 with IgM MGUS (31%). The neuropathy was subclinical in 6 patients (1 IgG, 1 IgA, and 4 IgM). Patients with IgG or IgA MGUS had a prominent motor impairment with electrophysiologic and morphologic findings suggestive of predominant axonal degeneration. No deposit of the M-protein in sural nerve and no reactivity of the M-protein with nerve was detected in these patients. Patients with IgM MGUS had a prominent sensory impairment with evidence of predominant demyelination. In 6 of these patients the M-protein reacted with the myelin-associated glycoprotein (MAG). The higher prevalence of neuropathy in patients with IgM MGUS may be related to the frequent reactivity of IgM M-proteins with MAG.
- Subjects :
- Adult
Aged
Autoimmune Diseases diagnosis
Demyelinating Diseases diagnosis
Demyelinating Diseases immunology
Electromyography
Epitopes immunology
Female
Humans
Male
Middle Aged
Myelin-Associated Glycoprotein
Neurologic Examination
Paraproteinemias diagnosis
Peripheral Nervous System Diseases diagnosis
Synaptic Transmission physiology
Autoimmune Diseases immunology
Blood Proteins immunology
Immunoglobulins metabolism
Myelin Proteins immunology
Paraproteinemias immunology
Peripheral Nervous System Diseases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6314
- Volume :
- 85
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Acta neurologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 1379409
- Full Text :
- https://doi.org/10.1111/j.1600-0404.1992.tb06033.x