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Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products.
- Source :
-
The Journal of biological chemistry [J Biol Chem] 1992 Aug 05; Vol. 267 (22), pp. 15692-700. - Publication Year :
- 1992
-
Abstract
- Three distinct but closely related classes of receptors that bind the Fc portion of immunoglobulin G (Fc gamma RI, -II, and -III) have been identified in humans. Only Fc gamma RI has high affinity for ligand and has a unique third extracellular domain (EC3). We have characterized three genes for human Fc gamma RI (A, B, and C). Each gene consists of six exons, spans 9.4 kilobase pairs, and localizes to chromosome 1. Although they are remarkably similar, genes B and C are notably different from A; in-frame stop codons are present in the EC3 domain of genes B and C, and deletions occur in a splice donor sequence of gene B. Four distinct Fc gamma RI transcripts were analyzed. One transcript, from gene A, would encode a transmembrane receptor with three external domains. A second transcript, an alternatively spliced product of gene B, would encode a two-external domain transmembrane receptor. Two transcripts, from genes B and C, have stop codons in EC3 and would be predicted to generate secreted receptors.
- Subjects :
- Amino Acid Sequence
Base Sequence
Blotting, Southern
Cell Line
Cloning, Molecular
DNA genetics
DNA isolation & purification
Humans
Immunoglobulin G metabolism
Leukocytes immunology
Molecular Sequence Data
Oligodeoxyribonucleotides
Oligonucleotide Probes
Polymerase Chain Reaction methods
RNA genetics
RNA isolation & purification
Receptors, IgG
Restriction Mapping
Sequence Homology, Nucleic Acid
Antigens, Differentiation genetics
Multigene Family
Receptors, Fc genetics
Transcription, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9258
- Volume :
- 267
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- The Journal of biological chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 1379234