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Cardiac inotropic effects of ethanol and calcium-channel modulators.
- Source :
-
Alcohol (Fayetteville, N.Y.) [Alcohol] 1992 Jul-Aug; Vol. 9 (4), pp. 293-7. - Publication Year :
- 1992
-
Abstract
- Our objective was to analyze the influence of ethanol ingestion on the in vitro inotropic effects of dihydropyridines alone, or in combination with ethanol, on atrial muscle from rats offered a liquid diet with ethanol ("ethanol rats," ER) or without ethanol ("normal rats," NR). Left atria from NR or ER were superfused with Tyrode's solution (36 degrees C) and driven at 1.5 Hz while recording tension. Bay K 8644 (BAYK) increased, while nimodipine or ethanol decreased, the tension developed and the velocity of development of tension. The preparations recovered rapidly from the effects of ethanol, but not from those of the dihydropyridines. The effects of ethanol and dihydropyridines in combination were the result of the additive or counteractive actions of the drugs. The effects of ethanol and nimodipine on ER preparations were not different from those observed in NR. The action of BAYK was significantly smaller in ER than in NR. In other words, chronic ingestion of ethanol reduced the positive inotropic effect of BAYK, but it did not modify the negative inotropic action of nimodipine or ethanol.
- Subjects :
- 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester pharmacology
Animals
Calcium Channels drug effects
Drug Interactions
In Vitro Techniques
Male
Nimodipine pharmacology
Rats
Rats, Inbred Strains
Stimulation, Chemical
Calcium Channels physiology
Dihydropyridines pharmacology
Ethanol pharmacology
Myocardial Contraction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0741-8329
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Alcohol (Fayetteville, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 1379050
- Full Text :
- https://doi.org/10.1016/0741-8329(92)90069-m