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The role of opsonins in the clearance of living and inert particles by cells of the reticuloendothelial system.

Authors :
JENKIN CR
ROWLEY D
Source :
The Journal of experimental medicine [J Exp Med] 1961 Sep 01; Vol. 114, pp. 363-74.
Publication Year :
1961

Abstract

An investigation of the clearance of bacteria and colloids from the blood stream of mice has shown that both living and inert particles require serum factors (opsonins) in order that they may be phagocytosed by the macrophages of the reticuloendothelial system. It has been demonstrated that after the injection of a large dose of colloid there is a depletion of these serum opsonins which appears to account for the reduced rate of clearance of a second dose of colloid or living bacteria, since replacement of these factors leads to normal clearance. The significance of these results is discussed and it is suggested that in "blockaded" animals there is a depletion of serum opsonins rather than a saturation of phagocytic cells.

Details

Language :
English
ISSN :
0022-1007
Volume :
114
Database :
MEDLINE
Journal :
The Journal of experimental medicine
Publication Type :
Academic Journal
Accession number :
13789822
Full Text :
https://doi.org/10.1084/jem.114.3.363