Ethanol inhibition of N-methyl-D-aspartate-activated ion current in rat hippocampal neurons is not competitive with glycine.

Authors :: Peoples RW
Weight FF
Source :: Brain research [Brain Res] 1992 Feb 07; Vol. 571 (2), pp. 342-4.
Publication Year :: 1992
Abstract: The interaction of ethanol with glycine at the N-methyl-D-aspartate (NMDA)-activated ion channel was investigated in voltage-clamped rat cultured hippocampal neurons. As shown previously, glycine increased, and ethanol inhibited, the NMDA-activated current in these cells. Concentration-response data for glycine (0.1-100 microM) indicate that the inhibition of NMDA-activated current by ethanol does not involve a competitive interaction with glycine. Thus, ethanol appears to inhibit NMDA-activated current at a locus different from the glycine modulatory site.

Subjects :: Animals
Cells, Cultured
Dose-Response Relationship, Drug
Drug Interactions
Fetus
Ion Channels drug effects
Kinetics
N-Methylaspartate antagonists & inhibitors
Neurons drug effects
Rats
Ethanol pharmacology
Glycine pharmacology
Hippocampus physiology
Ion Channels physiology
N-Methylaspartate pharmacology
Neurons physiology

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