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Potassium secretion by colonic mucosal cells after potassium adaptation.
Potassium secretion by colonic mucosal cells after potassium adaptation.
- Source :
-
The American journal of physiology [Am J Physiol] 1976 Oct; Vol. 231 (4), pp. 987-94. - Publication Year :
- 1976
-
Abstract
- Recent studies have demonstrated that chronic potassium loading increases Na-K-ATPase specific activity in kidney tissue and suggest that this enzyme plays a role in renal potassium adaptation. Studies of fluid and electrolyte movement, potential difference (PD), AND Na-K-ATPase were performed in colon and jejunum of the rat in order to further characterize the relationship of Na-K-ATPase to potassium secretion. Experimental rats fed 2.6 meq K/gm diet for 7 days were compared to a control group fed 0.13 meq K/gm. In the colon, chronic potassium loading increased potassium secretion from 0.8 +/- 0.2 to 3.9 +/- 0.9 mueq/min per g tissue (P less than 0.01) and PD from 27 +/- 5.0 to 54 +/- 2.6 mV (P less than 0.001), lumen negative, as Na-K-ATPase increased from 5.0 +/- 0.5 to 11.4 +/- 1.0 muM Pi/mg protein per h (P less than 0.001). In contrast, there was no change in PD, potassium movement, or Na-K-ATPase in the jejunum of potassium-loaded rats. Colonic movement of water, sodium, and chloride was similar in the control and potassium-loaded rats. These results indicate that increased Na-K-ATPase is associated with both increased PD and increased potassium secretion in the colon and provide additional evidence suggesting that Na-K-ATPase may be important in the control of transepithelial potassium movement.
- Subjects :
- Action Potentials
Adrenal Glands physiology
Animals
Biological Transport, Active
Colon enzymology
Diet
Intestinal Mucosa enzymology
Jejunum metabolism
Kidney Tubules, Distal metabolism
Male
Nephrons metabolism
Nucleotidases metabolism
Potassium administration & dosage
Rats
Sodium metabolism
Water-Electrolyte Balance
Adenosine Triphosphatases metabolism
Colon metabolism
Intestinal Mucosa metabolism
Potassium metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9513
- Volume :
- 231
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The American journal of physiology
- Publication Type :
- Academic Journal
- Accession number :
- 136207
- Full Text :
- https://doi.org/10.1152/ajplegacy.1976.231.4.987