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SPEM impairment in drug-naive schizophrenic patients: evidence for a trait marker.
- Source :
-
Biological psychiatry [Biol Psychiatry] 1992 Nov 15; Vol. 32 (10), pp. 891-902. - Publication Year :
- 1992
-
Abstract
- Smooth-pursuit eye movements (SPEM) were assessed in healthy subjects and in drug-naive, chronic, and residual schizophrenic patients. SPEM gain was found to be decreased in all the schizophrenic patients who also exhibited a significant increase in the rate of saccades. The frequency of square-wave jerks was the same in schizophrenic patients and normal controls, suggesting that the primary abnormality in schizophrenic patients was a low gain rather than a defect of the saccadic system. Patients were retested 1 month later, and stability of gain was high even in formerly drug-naive subjects who had been treated for 1 month with neuroleptic drugs. Altogether these results confirm the conclusions of most previous studies, extend them to drug-naive schizophrenic patients, and favor the hypothesis that SPEM impairment is a trait marker in schizophrenia.
- Subjects :
- Adult
Antipsychotic Agents therapeutic use
Chronic Disease
Female
Humans
Male
Pursuit, Smooth drug effects
Risk Factors
Saccades drug effects
Saccades genetics
Schizophrenia diagnosis
Schizophrenia drug therapy
Genetic Markers genetics
Pursuit, Smooth genetics
Schizophrenia genetics
Schizophrenic Psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3223
- Volume :
- 32
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 1361365
- Full Text :
- https://doi.org/10.1016/0006-3223(92)90178-3