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Possible enhancing effect of the immunosuppressive agent, 6-mercaptopurine(6-MP) on focal lesion development in cirrhotic liver induced by carbon tetrachloride but not furfural in F344 rats.
- Source :
-
Carcinogenesis [Carcinogenesis] 1992 Aug; Vol. 13 (8), pp. 1365-9. - Publication Year :
- 1992
-
Abstract
- The modifying effects of an immunosuppressive agent, 6-mercaptopurine (6-MP), on development of focal lesions in liver cirrhosis models induced by carbon tetrachloride (CCl4) or furfural were studied in male F344 rats. Feeding of 6-MP at 50 p.p.m. for 20 weeks to animals with pre-existing liver cirrhosis caused immunosuppression, and significantly enhanced the induction of gamma-glutamyltranspeptidase (GGT)-positive foci and nodules in the CCl4 but not furfural case. Glutathione S-transferase P (GST-P)-positive preneoplastic lesions were not affected. Moreover, phenobarbital (PB) also enhanced the induction of GGT-positive hepatocellular lesions only in the CCl4-induced liver cirrhosis model, no promotion influence being exerted after treatment with the non-carcinogenic furfural. This study, therefore, suggests that 6-MP can enhance the induction of one type of preneoplastic foci and nodules and that essential differences exist between focal lesions arising in cirrhotic livers caused by CCl4 as opposed to furfural.
- Subjects :
- Alkaline Phosphatase analysis
Animals
Aspartate Aminotransferases analysis
Carbon Tetrachloride
Drug Synergism
Furaldehyde
Glutathione Transferase analysis
Liver drug effects
Liver enzymology
Liver Cirrhosis, Experimental chemically induced
Liver Cirrhosis, Experimental enzymology
Male
Phenobarbital pharmacology
Precancerous Conditions chemically induced
Rats
Rats, Inbred F344
gamma-Glutamyltransferase analysis
Liver Cirrhosis, Experimental pathology
Liver Neoplasms chemically induced
Mercaptopurine adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0143-3334
- Volume :
- 13
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 1354082
- Full Text :
- https://doi.org/10.1093/carcin/13.8.1365